A sail boat arrives in New York without a living soul but a zombie that attacks two guards from the Coast Guard. The daughter of the owner of the ship, Anne Bowles, requests information about her missing father that was in the Antilles to the detectives that are investigating the crime without success. She meets the journalist Peter West and they decide to investigate what might have happened to her father. They travel to Matul Island with Brian Hull and Susan Barrett in their boat. Once in the tropical island, they meet Dr. David Menard, who is trying to find a cure to a disease that brings dead back to life, turning them into zombies that eat human flesh, increasing the menace against the group.